HLA-B, HLA-C and KIR improve the predictive value of IFNL3 for Hepatitis C spontaneous clearance
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چکیده
منابع مشابه
بررسی آلو آنتی ژنهای HLA-B، HLA-A و HLA-C در جمعیتی از استان اصفهان
A random sample of 500 healthy unrelated subjects from Esfahan province were HLA typed for A, 8 and C locus antigens. The lymphocytes were separated from 5 ml of whole peripheral blood and were typed for HLA _ A, 8 and C by using the standard two stage microlymphocytotoxicity NIH technique. The findings suggest that in the study population, frequency of HLA-Al' A2, A3, Ag HLA-8s, 83S and HLA-CW...
متن کاملGenetic Diversity of the KIR/HLA System and Susceptibility to Hepatitis C Virus-Related Diseases
BACKGROUND The variability in the association of host innate immune response to Hepatitis C virus (HCV) infection requires ruling out the possible role of host KIR and HLA genotypes in HCV-related disorders: therefore, we therefore explored the relationships between KIR/HLA genotypes and chronic HCV infection (CHC) as they relate to the risk of HCV-related hepatocarcinoma (HCC) or lymphoprolife...
متن کاملMaternal KIR and fetal HLA-C: a fine balance.
NK cell effector function is regulated by a range of activating and inhibitory receptors, and many of their known ligands are MHC class I molecules. Human NK receptors encoded by the Killer immunoglobulin-like receptor (KIR) gene family recognize polymorphic HLA-C as well as some HLA-A and HLA-B molecules. KIRs are expressed by uterine NK (uNK) cells, which are distinctive NK cells directly in ...
متن کاملDistribution of HLA-A, -B, and -C Alleles and HLA/KIR Combinations in Han Population in China
We investigated polymorphisms of the human leukocyte antigen (HLA) class I (A, B, and C) loci of a Han population (n, 239) from the Yunnan province, Southwest China, using high-resolution polymerase chain reaction-Luminex (PCR-Luminex) typing. We combined the HLA data from this study with the KIR genotypes from a previous study of this Han population to analyze the combination of KIR/HLA ligand...
متن کاملGenetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection
Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous clearance. To overcome anticipated limitations of small sample size, primary a...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-017-17531-7